Age estimation is of great significance in the fields of criminal investigation and forensic identification. It can provide the age information of individuals to judicial departments to facilitate the development of judicial work. In recent years, age estimation methods expanded from the morphological level to the molecular biology level. With the rapid development of epigenetics represented by DNA methylation, and the advancement of DNA methylation detection technology together with the detection platform, many age estimation methods based on DNA methylation biomarkers, or using several biological fluids, such as blood, blood stains, saliva, semen stains, etc. are developed. Currently, researches related to age estimation based on DNA methylation are relatively widely carried out. This paper summarizes the researches on age estimation based on DNA methylation, in order to provide references for related studies and forensic applications.
题目: 基于DNA甲基化推断年龄的研究进展.
摘要: 年龄推断在刑事侦查及司法鉴定领域具有重要的意义，可以为司法部门提供个体的年龄信息，有助于司法工作的开展。近年来，年龄推断方法已从既往的形态学层面拓展至分子生物学层面。随着以DNA甲基化为代表的表观遗传学的迅速发展，以及DNA甲基化检测技术及检测平台不断提升，许多基于DNA甲基化的生物标记及利用各种生物体液（如血液、血痕、唾液、精斑等）的年龄推断方法不断发展。目前，基于DNA甲基化推断年龄的相关研究较多，本文对该方面的研究进行归纳总结，希望能为相关研究和法医学应用提供参考。.
关键词: 法医遗传学；DNA甲基化；年龄测定；综述.
Keywords: forensic genetics; DNA methylation; age determination; review.
Copyright© by the Editorial Department of Journal of Forensic Medicine.