Immune Cellular Evaluation Following Newborn Screening For Severe T and B Cell Lymphopenia

Johannes Wolf; Karolin Dahlenburg; Stephan Borte

Immune Cellular Evaluation Following Newborn Screening For Severe T and B Cell Lymphopenia

EJIFCC. 2019 Nov 25;30(4):396-406. eCollection 2019 Nov.

Authors

Johannes Wolf^{1

2}, Karolin Dahlenburg³, Stephan Borte^{2

4}

Affiliations

¹ Municipal Hospital St. Georg Leipzig, Academic Teaching Hospital of the University Leipzig, Department of Laboratory Medicine and Microbiology, Leipzig, Germany.
² Immuno Deficiency Center Leipzig (IDCL) at Hospital St. Georg Leipzig, Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiency Diseases, Leipzig, Germany.
³ Faculty of Medicine, University Leipzig, Germany.
⁴ Municipal Hospital St. Georg Leipzig, Academic Teaching Hospital of the University Leipzig, Department of Pediatrics, Leipzig, Germany.

PMID: 31832054
PMCID: PMC6893892

Abstract

Newborn screening (NBS) for severe T and/or B cell lymphopenia to identify neonates with severe combined immunodeficiencies (SCID) or agammaglobulinemia rapidly after birth has paved its way into clinical practice. Debate exists on the concept and strategy for rapid verification and stratification of the cellular immune status of positively screened infants. We provide impulses for harmonization of flow cytometric approaches to allow rapid integration in the growing number of immunological laboratories involved in follow-up and subdivision of SCID and non-SCID entities.

Keywords: B cell lymphopenia; T cell lymphopenia; newborn screening; severe combined immunodeficiency.

Publication types

Review