Abstract
The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Cycle / physiology
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Checkpoint Kinase 1 / metabolism
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DNA Damage / physiology*
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DNA Repair / physiology
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DNA Replication / physiology*
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DNA-Binding Proteins / metabolism*
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Genomic Instability
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Humans
Substances
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DNA-Binding Proteins
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SPRTN protein, human
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CHEK1 protein, human
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Checkpoint Kinase 1