A model of DNA damage response activation at stalled replication forks by SPRTN

Nat Commun. 2019 Dec 12;10(1):5671. doi: 10.1038/s41467-019-13610-7.

Abstract

The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Cycle / physiology
  • Checkpoint Kinase 1 / metabolism
  • DNA Damage / physiology*
  • DNA Repair / physiology
  • DNA Replication / physiology*
  • DNA-Binding Proteins / metabolism*
  • Genomic Instability
  • Humans

Substances

  • DNA-Binding Proteins
  • SPRTN protein, human
  • CHEK1 protein, human
  • Checkpoint Kinase 1