Iron oxide nanoparticle core-shell magnetic microspheres: Applications toward targeted drug delivery

Srinivasan Ayyanaar; Mookkandi Palsamy Kesavan; Chandrasekar Balachandran; Swetha Rasala; Perumal Rameshkumar; Shin Aoki; Jegathalaprathaban Rajesh; Thomas J Webster; Gurusamy Rajagopal

doi:10.1016/j.nano.2019.102134

Iron oxide nanoparticle core-shell magnetic microspheres: Applications toward targeted drug delivery

Nanomedicine. 2020 Feb:24:102134. doi: 10.1016/j.nano.2019.102134. Epub 2019 Dec 10.

Authors

Srinivasan Ayyanaar¹, Mookkandi Palsamy Kesavan², Chandrasekar Balachandran³, Swetha Rasala⁴, Perumal Rameshkumar⁵, Shin Aoki⁶, Jegathalaprathaban Rajesh⁷, Thomas J Webster⁸, Gurusamy Rajagopal⁹

Affiliations

¹ PG and Research Department of Chemistry, Chikkanna Government Arts College, Tiruppur, Tamilnadu, India.
² Department of Chemistry, Hajee Karutha Rowther Howdia College, Uthamapalayam, Tamil Nadu, India.
³ Faculty of Pharmaceutical Sciences, Tokyo University of Science, Yamazaki, Noda, Japan.
⁴ Centre for Research in Medical Devices (CÚRAM), National University of Ireland Galway, Galway, Ireland.
⁵ Department of Chemistry, Kalasalingam Academy of Research and Education, Krishnankoil, Tamil Nadu, India.
⁶ Faculty of Pharmaceutical Sciences, Tokyo University of Science, Yamazaki, Noda, Japan; Research Institute of Science and Technology, Tokyo University of Science, Yamazaki, Noda, Japan.
⁷ Chemistry Research Centre, Mohamed Sathak Engineering College, Kilakarai, Tamil Nadu, India. Electronic address: mkuraji@gmail.com.
⁸ Department of Chemical Engineering, Northeastern University, Boston, MA, USA. Electronic address: th.webster@neu.edu.
⁹ PG and Research Department of Chemistry, Chikkanna Government Arts College, Tiruppur, Tamilnadu, India. Electronic address: rajagopal18@yahoo.com.

PMID: 31830615
DOI: 10.1016/j.nano.2019.102134

Abstract

This study describes a sensitive reactive oxygen species (ROS)-responsive lecithin (LEC) incorporated iron oxide nanoparticle (Fe₃O₄ NP) system with potent anti-inflammatory properties and even more so when the antioxidant drug curcumin (CUR) is encapsulated in the PLGA hybrid magnetic microsphere system (Fe₃O₄@LEC-CUR-PLGA-MMS). The delivery system is responsive to ROS including an H₂O₂ environment to release the payload (CUR) drug. Greater cytotoxicity properties were observed in the presence of Fe₃O₄@LEC-CUR-PLGA-MMS against A549 and HeLa S3 cells with IC₅₀ values after 24 h of 10 and 12 μg/mL and 10 and 20 μg/mL, respectively. The present Fe₃O₄@LEC-CUR-PLGA-MMS system demonstrated much better in vitro cytotoxicity, cellular morphological changes and moreover an ability to limit colony formation for A549 and HeLa S3 cancer cell lines than non-cancerous cells, and thus, should be further studied for a wide range of medical applications.

Keywords: Cytotoxicity; Lecithin; Magnetic core microsphere; Poly(D, L-lactide-co-glycolic acid); Targeted drug delivery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

A549 Cells
Curcumin / administration & dosage
Curcumin / chemistry
Drug Delivery Systems / methods
Ferric Compounds / chemistry*
HeLa Cells
Humans
Lecithins / chemistry
Metal Nanoparticles / chemistry*
Microspheres
Reactive Oxygen Species / metabolism
Spectroscopy, Fourier Transform Infrared

Substances

Ferric Compounds
Lecithins
Reactive Oxygen Species
ferric oxide
Curcumin