Role of allograft inflammatory factor-1 in pathogenesis of diseases

Immunol Lett. 2020 Feb:218:1-4. doi: 10.1016/j.imlet.2019.12.002. Epub 2019 Dec 9.

Abstract

Allograft inflammatory factor-1 (AIF-1) is a 17 kDa calcium-binding protein produced by monocytes, macrophages, and lymphocytes; its synthesis is induced by INF-γ. The AIF-1 gene is located in the major histocompatibility complex (MHC) class III region on chromosome 6p21.3, surrounded by surface glycoprotein genes and complement cascade protein genes as well as TNF-α, TNF-β, and NF-κB genes. Increased expression of AIF-1 was observed in several diseases, including endometriosis, breast cancer, atherosclerosis, rheumatoid arthritis, and fibrosis. In this review, we summarise the role of AIF-1 in allograft rejection and the pathogenesis of diseases.

Keywords: Allograft inflammatory factor-1; Atherosclerosis; Graft; Rheumatoid arthritis.

Publication types

  • Review

MeSH terms

  • Allografts / immunology
  • Allografts / metabolism
  • Animals
  • Calcium-Binding Proteins / genetics*
  • Calcium-Binding Proteins / metabolism*
  • Disease Susceptibility*
  • Gene Expression Regulation
  • Graft Rejection / genetics
  • Graft Rejection / immunology
  • Graft Rejection / metabolism
  • Humans
  • Lymphocytes / immunology
  • Lymphocytes / metabolism
  • Macrophages / immunology
  • Macrophages / metabolism
  • Microfilament Proteins / genetics*
  • Microfilament Proteins / metabolism*
  • Monocytes / immunology
  • Monocytes / metabolism
  • Signal Transduction

Substances

  • AIF1 protein, human
  • Calcium-Binding Proteins
  • Microfilament Proteins