Abstract
We herein report a new approach for RNA interference, so-called "build-up RNAi" approach, where single-strand circular RNAs with a photocleavable unit or disulfide moiety were used as siRNA precursors. The advantages of using these circular RNA formats for RNAi were presented in aspects of immunogenicity and cellular uptake.
MeSH terms
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Apolipoproteins B / antagonists & inhibitors
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Apolipoproteins B / genetics
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Apolipoproteins B / metabolism
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RNA Interference*
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RNA Precursors / chemical synthesis
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RNA Precursors / chemistry*
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RNA Precursors / radiation effects
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RNA, Circular / chemical synthesis
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RNA, Circular / chemistry*
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RNA, Small Interfering / chemistry*
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RNA, Small Interfering / metabolism
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Ultraviolet Rays
Substances
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Apolipoproteins B
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RNA Precursors
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RNA, Circular
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RNA, Small Interfering