Terphenyl derivatives and terpenoids from a wheat-born mold Aspergillus candidus

JunJie Han; FangMing Lu; Li Bao; HanYing Wang; BaoSong Chen; ErWei Li; ZhengDi Wang; LiPing Xie; ChangBin Guo; YanFen Xue; YanHe Ma; HongWei Liu

doi:10.1038/s41429-019-0266-9

Terphenyl derivatives and terpenoids from a wheat-born mold Aspergillus candidus

J Antibiot (Tokyo). 2020 Mar;73(3):189-193. doi: 10.1038/s41429-019-0266-9. Epub 2019 Dec 11.

Authors

JunJie Han^{1

2

3}, FangMing Lu⁴, Li Bao^{1

3}, HanYing Wang⁴, BaoSong Chen^{1

3}, ErWei Li^{1

3}, ZhengDi Wang⁵, LiPing Xie⁵, ChangBin Guo⁵, YanFen Xue², YanHe Ma⁶, HongWei Liu^{7

8}

Affiliations

¹ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
² State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
³ Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.
⁴ College of Life Sciences, Hebei University, Baoding, 071002, China.
⁵ Department of Chemistry, Capital Normal University, Beijing, 100048, China.
⁶ State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. mayanhe@im.ac.cn.
⁷ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. liuhw@im.ac.cn.
⁸ Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China. liuhw@im.ac.cn.

PMID: 31827255
DOI: 10.1038/s41429-019-0266-9

Abstract

A new p-terphenyl derivative aspergicandidusin A (1), a new cleistanthane diterpenoid 6-deoxyaspergiloid C (13), and 12 known compounds (2-12, and 14) were isolated from the mold Aspergillus candidus. The structures of the new compounds were elucidated by spectral analysis of NMR and MS data. The absolute configuration of C-1 in 13 was determined via the circular dichroism data of the [Rh₂(OCOCF₃)₄] complex. Compounds 2-8 and 11 showed moderate inhibitory activity against K562 cell lines with the IC₅₀ value in the range from 17.9 to 46.3 μM. Compound 13 exhibited moderate cytotoxicity against HepG2 cells with the IC₅₀ value of 47.7 μM. Compounds 11 and 12 exhibited moderate activity against the growth of S. aureus with MIC value of 6.25 μM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / metabolism
Antineoplastic Agents / pharmacology
Aspergillus / classification
Aspergillus / metabolism*
Hep G2 Cells
Humans
K562 Cells
Models, Molecular
Molecular Structure
Terpenes / chemistry
Terpenes / metabolism*
Terpenes / pharmacology
Terphenyl Compounds / chemistry
Terphenyl Compounds / metabolism*
Terphenyl Compounds / pharmacology
Triticum / microbiology*

Substances

Antineoplastic Agents
Terpenes
Terphenyl Compounds