Objective: To study the imaging performance and pulmonary function of pneumoconiosis patients at stage three. Methods: 89 cases of pneumoconiosis patients at stage three for high thousand volt back chest, chest CT, pulmonary function, analysis the relationship of high thousand volt back chest, chest CT manifestations and pulmonary function. Results: In patients with chest X-ray progressive massive fibrosis range of 2.31-102.95 cm(2), divide patients according to the X-ray performance into three groups, the difference of each group pulmonary function index FVC、FEV(1)、PEF、MEF(75%)、MEF(50%)、MEF(25%)、MVV is statistically significant (P<0.01) , the difference of FEV(1)/FVC%、RV/TLC、DLCO is no statistical significance (P>0.05) . Checked by related, in pneumoconiosis patients at stage three, the X-ray manifestations and pulmonary function index FVC、FEV(1)、FEV(1)/FVC%、PEF、MEF(75%)、MEF(50%)、MEF(25%)、MVV、DLCO showed a negative correlation (r=-0.326, -0.438, -0.251, -0.344, -0.317, -0.337, -0.425, -0.347, -0.230) . With the deterioration of the X-ray imaging findings, pulmonary function index FVC、FEV(1)、FEV(1)/FVC%、PEF、MEF(75%)、MEF(50%)、MEF(25%)、MVV、DLCO is a trend of decrease (P<0.05) . The X-ray changes is not associated with RV/TLC. By linear regression analysis, FVC、FEV(1)、FEV(1)/FVC%、PEF、MEF(75%)、MEF(50%)、MEF(25%)、MVV、DLCO regression equation are meaningful. The RV/TLC regression equations is meaningless. The volume of the patients with chest CT progressive massive fibrosis range of 4.86~179.74 cm(3), divide patients according to the chest CT performance into three groups, the difference of each group pulmonary function index FVC、FEV(1)、PEF、MEF(75%)、MEF(50%)、MEF(25%)、MVV、RV/TLC is statistically (P<0.05) , the difference of FEV(1)/FVC%、DLCO is no statistical significance (P>0.05) . Checked by related, in pneumoconiosis patients at stage three, chest CT manifestations and pulmonary function index FVC、FEV(1)、FEV(1)/FVC%、PEF、MEF(75%)、MEF(50%)、MEF(25%)、MVV showed a negative correlation (r=-0.360, -0.419, -0.256, -0.432, -0.366, -0.326, -0.254, -0.405, ) , It is not associated with the RV/TLC、DLCO. With the deterioration of the chest CT imaging findings, pulmonary function index FVC、FEV(1)、FEV(1)/FVC%、PEF、MEF(75%)、MEF(50%)、MEF(25%)、MVV is a trend of decrease (P<0.05) . By linear regression analysis, FVC、FEV(1)、FEV(1)/FVC%、PEF、MEF(75%)、MEF(50%)、MEF(25%)、MVV regression equations are meaningful. The RV/TLC、DLCO regression equations are meaningless. Conclusion: It is correlated with chest X-ray, chest CT manifestations and pulmonary function in pneumoconiosis patients at stage three, that could help guide clinicians comprehensive evaluation in patients with pulmonary function status.
目的： 研究尘肺病叁期影像学表现与肺功能之间的相关性。 方法： 于2019年1月，选择2014年至2018年淄博市职业病防治院收治的89例尘肺病叁期患者，分析其X射线高千伏后前位胸片、胸部CT、肺功能检查资料，探讨高仟伏胸片、胸部CT表现与肺功能的关系。将患者按照胸片融合灶（PMF）总面积分为小阴影集组、2 cm×1 cm<S(PFM)<40 cm(2)组、S(PMF)≥40 cm(2)组，将患者按照胸部CT片PMF总体积分为0~50 cm(2)组、51~100 cm(3)组和>100 cm(2)组。分析各组患者用力肺活量（FVC）、第1秒用力呼气量（FEV(1)）、最大呼气流量（MEF）、最大通气量（MVV）、残气/肺总量（RV/TLC）；一氧化碳弥散量（DLLO）等指标。用SPSS 17.0软件进行统计分析，计量资料以x±s表示，组间比较采用秩和检验，用Person检验进行相关分析。 结果： 患者胸片PMF面积2.31~102.95 cm(2)，各组间肺功能指标FVC、FEV(1)、PEF、MEF(75%)、MEF(50%)、MEF(25%)、MVV差异有统计学意义（P<0.01），FEV(1)/FVC%、RV/TLC、DLCO差异无统计学意义（P>0.05）。尘肺叁期胸片表现与肺功能指标FVC、FEV(1)、FEV1/FVC%、PEF、MEF(75%)、MEF(50%)、MEF(25%)、MVV、DLCO呈负相关（r=-0.326、-0.438、-0.251、-0.344、-0.317、-0.337、-0.425、-0.347、-0.230，均P<0.05）。胸片改变与RV/TLC不相关。经线性回归分析，FVC、FEV(1)、FEV(1)/FVC%、PEF、MEF(75%)、MEF(50%)、MEF(25%)、MVV、DLCO回归方程均有意义（R(2)<0.200）。RV/TLC回归方程无意义。患者胸部CT PMF的总体积4.86~179.74 cm(3)，患者CT片各组间肺功能指标FVC、FEV(1)、PEF、MEF(75%)、MEF(50%)、MEF(25%)、MVV、RV/TLC差异有统计学意义（P<0.05），FEV(1)/FVC%、DLCO差异无统计学意义（P>0.05）。经相关检验，尘肺叁期胸部CT表现与肺功能指标FVC、FEV(1)、FEV(1)/FVC%、PEF、MEF(75%)、MEF(50%)、MEF(25%)、MVV呈负相关（r=-0.360、-0.419、-0.256、-0.432、-0.366、-0.326、-0.254、-0.405，均P<0.05）。经线性回归分析，FVC、FEV(1)、FEV(1)/FVC%、PEF、MEF(75%)、MEF(50%)、MEF(25%)、MVV回归方程均有意义（R(2)<0.300）。 结论： 尘肺病叁期胸片、胸部CT表现与肺功能有相关性，有助于指导临床医师综合评估患者肺功能状况。.
Keywords: Correlation; Imaging; Pneumoconiosis; Pulmonary function.