Long-term gait measurements in daily life: Results from the Berlin Aging Study II (BASE-II)

PLoS One. 2019 Dec 11;14(12):e0225026. doi: 10.1371/journal.pone.0225026. eCollection 2019.

Abstract

Background: Walking ability is an important prerequisite for activity, social participation and independent living. While in most healthy adults, this ability can be assumed as given, limitations in walking ability occur with increasing age. Furthermore, slow walking speed is linked to several chronic conditions and overall morbidity. Measurements of gait parameters can be used as a proxy to detect functional decline and onset of chronic conditions. Up to now, gait characteristics used for this purpose are measured in standardized laboratory settings. There is some evidence, however, that long-term measurements of gait parameters in the living environment have some advantages over short-term laboratory measurements.

Methods: We evaluated cross-sectional data from an accelerometric sensor worn in a subgroup of 554 participants of the Berlin Aging Study II (BASE-II). Data from the two BASE-II age groups (age between 22-36 years and 60-79 years) were used for the current analysis of accelerometric data for a minimum of two days and a maximum of ten days were available. Real world walking speed, number of steps, maximum coherent distance and total distance were derived as average data per day. Linear regression analyses were performed on the different gait parameters in order to identify significant determinants. Additionally, Mann-Whitney-U-tests were performed to detect sex-specific differences.

Results: Age showed to be significantly associated with real world walking speed and with the total distance covered per day, while BMI contributed negatively to the number of walking steps, maximum coherent distance and total distance walked. Additionally, sex was associated with walking steps. However, R2-values for all models were low. Overall, women had significantly more walking steps and a larger coherent distance per day when compared to men. When separated by age group, this difference was significant only in the older participants. Additionally, walking speed was significantly higher in women compared to men in the subgroup of older people.

Conclusions: Age- and sex-specific differences have to be considered when objective gait parameters are measured, e.g. in the context of clinical risk assessment. For this purpose normative data, differentiating for age and sex would have to be established to allow reliable classification of long-term measurements of gait.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aging / physiology*
  • Cross-Sectional Studies
  • Female
  • Gait / physiology*
  • Germany
  • Humans
  • Male
  • Middle Aged
  • Sex Characteristics*
  • Walking / physiology*
  • Walking Speed
  • Young Adult

Grants and funding

The BASE-II research project (Co-PIs are Lars Bertram, Ilja Demuth, Denis Gerstorf, Ulman Lindenberger, Graham Pawelec, Elisabeth Steinhagen-Thiessen, and Gert G. Wagner) is supported by the German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF) under grant numbers #16SV5536K, #16SV5537, #16SV5538, #16SV5837, #01UW0808, 01GL1716A and 01GL1716B. Another source of funding is the Max Planck Institute for Human Development, Berlin, Germany. Additional contributions (e.g., equipment, logistics, personnel) are made from each of the other participating sites. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. T.M., C.L. and M.D. are associates of Trium Analysis Online GmbH, (Munich, Germany) as the developing company of the actibelt tri-axial accelerometer. These authors were involved in the conceptualization of the study, data preparation, statistical analysis and writing of the manuscript. However, Trium had no role in financing the BASE-II-study or the preparation of the manuscript presented here. Timur Nuritdinow and Christian Lederer are employees of the Sylvia Lawry Centre for Multiple Sclerosis Research. The specific roles of these authors are articulated in the author contributions section. The involvement of these authors does not alter our adherence to PLOS ONE policies on internationally-accepted standards for research practice and reporting, including data management, figure preparation, reproducibility, and reporting guidelines as well as sharing data and materials.