In vitro radiobiological parameters of human sarcoma cell lines

R R Weichselbaum; M A Beckett; M A Simon; C McCauley; D Haraf; A Awan; B Samuels; J Nachman; A Dritschilo

doi:10.1016/0360-3016(88)90129-0

In vitro radiobiological parameters of human sarcoma cell lines

Int J Radiat Oncol Biol Phys. 1988 Oct;15(4):937-42. doi: 10.1016/0360-3016(88)90129-0.

Authors

R R Weichselbaum¹, M A Beckett, M A Simon, C McCauley, D Haraf, A Awan, B Samuels, J Nachman, A Dritschilo

Affiliation

¹ Michael Reese/University of Chicago Center for Radiation Therapy, Department of Radiation and Cellular Oncology, IL 60637.

PMID: 3182333
DOI: 10.1016/0360-3016(88)90129-0

Abstract

In vitro radiobiologic survival parameters have been determined for 7 human osteosarcoma, 5 human soft tissue and bone sarcomas, and 4 Ewing's sarcoma cell lines. The mean D0 values were 99.5 +/- 11.6 cGy, 90.5 +/- 7.7 cGy and 95.8 +/- 7.9 cGy for osteosarcomas, soft tissue and bone sarcomas and Ewing's sarcomas, respectively. These in vitro survival data do not predict the clinical radiation resistance generally attributed to osteosarcomas and soft tissue and bone sarcomas, and do not differ substantially from the results obtained with the clinically radioresponsive Ewing's sarcomas.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Bone Neoplasms / physiopathology
Cell Line
Cell Survival / radiation effects
Humans
In Vitro Techniques
Osteosarcoma / physiopathology
Radiation Tolerance*
Sarcoma / physiopathology*
Sarcoma, Ewing / physiopathology
Soft Tissue Neoplasms / physiopathology

Abstract

Publication types

MeSH terms

Grants and funding