Abstract
This paper reports a case of tuberculosis relapse and chronic obstructive lung disease treated with rifampicin and isoniazid. The subsequent introduction of slow-release theophylline therapy revealed a delay in the theophylline elimination kinetics resulting in a toxic plasma level. Interference with hepatic microsomal enzymes is considered to occur.
MeSH terms
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Delayed-Action Preparations
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Drug Interactions
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Drug Therapy, Combination
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Humans
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Isoniazid / therapeutic use*
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Lung Diseases, Obstructive / complications
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Lung Diseases, Obstructive / drug therapy*
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Male
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Middle Aged
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Recurrence
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Rifampin / therapeutic use*
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Theophylline / administration & dosage
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Theophylline / blood
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Theophylline / pharmacokinetics*
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Theophylline / therapeutic use
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Time Factors
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Tuberculosis, Pulmonary / complications
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Tuberculosis, Pulmonary / drug therapy*
Substances
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Delayed-Action Preparations
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Theophylline
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Isoniazid
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Rifampin