Rifampicin-isoniazid and delayed elimination of theophylline: a case report

Int J Clin Pharmacol Res. 1988;8(4):275-7.

Abstract

This paper reports a case of tuberculosis relapse and chronic obstructive lung disease treated with rifampicin and isoniazid. The subsequent introduction of slow-release theophylline therapy revealed a delay in the theophylline elimination kinetics resulting in a toxic plasma level. Interference with hepatic microsomal enzymes is considered to occur.

Publication types

  • Case Reports

MeSH terms

  • Delayed-Action Preparations
  • Drug Interactions
  • Drug Therapy, Combination
  • Humans
  • Isoniazid / therapeutic use*
  • Lung Diseases, Obstructive / complications
  • Lung Diseases, Obstructive / drug therapy*
  • Male
  • Middle Aged
  • Recurrence
  • Rifampin / therapeutic use*
  • Theophylline / administration & dosage
  • Theophylline / blood
  • Theophylline / pharmacokinetics*
  • Theophylline / therapeutic use
  • Time Factors
  • Tuberculosis, Pulmonary / complications
  • Tuberculosis, Pulmonary / drug therapy*

Substances

  • Delayed-Action Preparations
  • Theophylline
  • Isoniazid
  • Rifampin