Modelling survival

Teresa A Zimmers; Leonidas G Koniaris

doi:10.7554/eLife.52959

Modelling survival

Elife. 2019 Dec 10:8:e52959. doi: 10.7554/eLife.52959.

Authors

Teresa A Zimmers^{1

2

3

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5

6

7}, Leonidas G Koniaris^{1

5

6

7}

Affiliations

¹ Department of Surgery, Indiana University School of Medicine, Indianapolis, United States.
² Anatomy Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, United States.
³ Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, United States.
⁴ Otolaryngology, Indiana University School of Medicine, Indianapolis, United States.
⁵ Simon Cancer Center, Indiana University, Indianapolis, United States.
⁶ Indiana Center for Musculoskeletal Health, Indiana University, Indianapolis, United States.
⁷ Center for Cachexia Research, Innovation and Therapy, Indiana University Purdue University Indianapolis, Indianapolis, United States.

Abstract

A new mouse model of sepsis can reproduce the long-term muscle weakness seen in patients who survive this life-threatening illness.

Keywords: chronic critical illness; human biology; immunology; inflammation; medicine; mitochondria; mouse; muscle; post-intensive care syndrome; sepsis.

Publication types

Comment

MeSH terms

Animals
Critical Illness*
Disease Models, Animal
Humans
Mice
Muscle Weakness
Sepsis*