Energy-Sensing Pathways in Ischemia: The Counterbalance Between AMPK and mTORC

Curr Pharm Des. 2019;25(45):4763-4770. doi: 10.2174/1381612825666191210152156.

Abstract

Stroke is an important cause of death and disability, and it is the second leading cause of death worldwide. In humans, middle cerebral artery occlusion (MCAO) is the most common cause of ischemic stroke. The damage occurs due to the lack of nutrients and oxygen contributed by the blood flow. The present review aims to analyze to what extent the lack of each of the elements of the system leads to damage and which mechanisms are unaffected by this deficiency. We believe that the specific analysis of the effect of lack of each component could lead to the emergence of new therapeutic targets for this important brain pathology.

Keywords: AMPK; Middle Cerebral Artery Occlusion (MCAO); Oxygen-glucose Deprivation (OGD); Stroke; mTORC1; nutrients deprivation; signaling..

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AMP-Activated Protein Kinases*
  • Amino Acids
  • Brain Ischemia*
  • Glucose
  • Humans
  • Infarction, Middle Cerebral Artery
  • Mechanistic Target of Rapamycin Complex 1*
  • Oxygen
  • Stroke*

Substances

  • Amino Acids
  • Mechanistic Target of Rapamycin Complex 1
  • AMP-Activated Protein Kinases
  • Glucose
  • Oxygen