Pharmacokinetics of intravenous administered two different high doses of ascorbic acid in healthy beagle dogs

Seula Lim; Ye-In Oh; Jong-Woo Jeong; Kun-Ho Song; Tae-Sung Koo; Kyoung-Won Seo

doi:10.5455/javar.2019.f371

Pharmacokinetics of intravenous administered two different high doses of ascorbic acid in healthy beagle dogs

J Adv Vet Anim Res. 2019 Oct 23;6(4):481-485. doi: 10.5455/javar.2019.f371. eCollection 2019 Dec.

Authors

Seula Lim¹, Ye-In Oh¹, Jong-Woo Jeong², Kun-Ho Song¹, Tae-Sung Koo², Kyoung-Won Seo¹

Affiliations

¹ Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea.
² Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea.

Abstract

Objective: We performed a randomized two-way crossover study to evaluate the pharmacokinetic profiles of two high-dose ascorbic acid (AA) after IV infusion in healthy beagle dogs.

Materials and methods: The dogs were administered IV AA at two doses of 1.5 and 3 gm/kg for 4 h, and the AA concentration in plasma and urine pH was measured before and after administration.

Results: The plasma concentrations of AA in both groups peaked 3 h after administration. Among the two groups, the urine pH was not significantly different (p = 0.1299-0.7944). High-dose IV AA did not induce serious adverse events in dogs.

Conclusion: The results of this study suggest that the high dose of AA which reaches the therapeutic dose for cancer and supports the safety of high-dose IV AA in dogs.

Keywords: Ascorbic acid; dog; pharmacokinetics.