Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression

Mol Cancer. 2019 Dec 9;18(1):180. doi: 10.1186/s12943-019-1110-3.

Abstract

Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP proteins as an oncogene or a tumor suppressor are unclear and controversial in cancers to date. Thus, the present review highlighted research history, dual roles of FOXP proteins as a tumor suppressor or an oncogene, their molecular networks with other proteins and noncoding RNAs, cellular immunotherapy targeting FOXP3, and clinical implications in cancer progression.

Keywords: Cellular immunotherapy; Clinical implications and cancer progression; FOXP proteins; Molecular networks; Noncoding RNAs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Combined Modality Therapy
  • Disease Progression
  • Disease Susceptibility
  • Forkhead Transcription Factors / chemistry
  • Forkhead Transcription Factors / genetics*
  • Forkhead Transcription Factors / metabolism*
  • Gene Expression Regulation, Neoplastic*
  • Gene Regulatory Networks*
  • Genes, Tumor Suppressor
  • Humans
  • Multigene Family*
  • Neoplasms / etiology*
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Oncogenes
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • Signal Transduction
  • Structure-Activity Relationship

Substances

  • Forkhead Transcription Factors