Benzoazacrown compound: a highly effective chelator for therapeutic bismuth radioisotopes

Ekaterina V Matazova; Bayirta V Egorova; Ekaterina A Konopkina; Gleb Yu Aleshin; Anastasia D Zubenko; Artem A Mitrofanov; Kirill V Karpov; Olga A Fedorova; Yuri V Fedorov; Stepan N Kalmykov

doi:10.1039/c9md00251k

Benzoazacrown compound: a highly effective chelator for therapeutic bismuth radioisotopes

Medchemcomm. 2019 Jul 4;10(9):1641-1645. doi: 10.1039/c9md00251k. eCollection 2019 Sep 1.

Authors

Affiliations

¹ Lomonosov Moscow State University , 119991 Leninskie Gory, 1/3 , Moscow , Russian Federation . Email: bayirta.egorova@gmail.com.
² A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences , 119991 Vavilova, 28, GSP-1 , Moscow , Russian Federation.
³ Science Data Software , Rockville , MD , USA.
⁴ Mendeleev University of Chemistry and Technology of Russia , 125047 Miusskaya sqr., 9 , Moscow , Russian Federation.
⁵ National Research Center "Kurchatov Institute" , 123098 Akademika Kurchatova sqr., 1 , Moscow , Russian Federation.

Abstract

A new benzoazacrown ligand H₄BATA was synthesized and its complexation ability towards bismuth cations was evaluated. Binding of cation occurs at room temperature in a few minutes and formed complex exhibits the same level of inertness as highly stable complex with the well-known H₄DOTA in biologically relevant and challenging media under in vivo conditions.