MiR-145: a potential biomarker of cancer migration and invasion

Wen-Xiu Xu; Zhen Liu; Fei Deng; Dan-Dan Wang; Xing-Wang Li; Tian Tian; Jian Zhang; Jin-Hai Tang

MiR-145: a potential biomarker of cancer migration and invasion

Am J Transl Res. 2019 Nov 15;11(11):6739-6753. eCollection 2019.

Authors

Wen-Xiu Xu^{1

2}, Zhen Liu^{1

2}, Fei Deng^{1

2}, Dan-Dan Wang¹, Xing-Wang Li³, Tian Tian³, Jian Zhang¹, Jin-Hai Tang^{1

2}

Affiliations

¹ Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, P. R. China.
² The First Clinical School of Nanjing Medical University Nanjing 210029, P. R. China.
³ School of Clinical Medicine, Xuzhou Medical University 209 Tongshan Road, Xuzhou 221004, P. R. China.

PMID: 31814885
PMCID: PMC6895535

Abstract

MircoRNAs (miRNAs) are a diverse family of highly-conserved small non-coding RNAs, which range from approximately 18 to 25 nucleotides in size. They regulate gene expression transcriptionally or post-transcriptionally via binding to the 3'-untranslated region (3'-UTR) of target message RNAs (mRNAs). MiRNAs have emerged as molecular regulators that participate in physiological and pathological processes of diverse malignancies. Among them, miRNA-145 (miR-145) played a profound role in tumorigenesis and progression of various neoplasms. In this review, we summarized the recent findings regarding miR-145, to elucidate its functional roles in cell invasion and migration of diverse human malignancies, and considered it a potential biomarker for cancer diagnosis, screening, and prognosis.

Keywords: MiR-145; biomarker; cancers; invasion and migration.

Publication types

Review