Past, Present and Future of Flow Cytometry in Breast Cancer - A Systematic Review

Maria Andreou; Evrysthenis Vartholomatos; Haralampos Harissis; Georgios S Markopoulos; George A Alexiou

Past, Present and Future of Flow Cytometry in Breast Cancer - A Systematic Review

EJIFCC. 2019 Nov 25;30(4):423-437. eCollection 2019 Nov.

Authors

Maria Andreou¹, Evrysthenis Vartholomatos¹, Haralampos Harissis², Georgios S Markopoulos^{1

3}, George A Alexiou⁴

Affiliations

¹ Haematology Laboratory-Unit of Molecular Biology, University Hospital of Ioannina, Greece.
² Department of Surgery, University Hospital of Ioannina, Greece.
³ Laboratory of Biology, Department of Medicine, Faculty of Medicine, School of Health Sciences, Ioannina, Greece.
⁴ Department of Neurosurgery, University Hospital of Ioannina, Greece.

PMID: 31814815
PMCID: PMC6893890

Abstract

Breast cancer is the most common malignancy in women worldwide. In this systematic review 28 studies were taken into account, in order to evaluate the role of DNA content and cell cycle phases, measured by flow cytometry in breast cancer. Presence of aneuploidy and S-phase fraction have been extensively studied as a prognostication tool. With the current dawn of the age of intraoperative flow cytometry the present systematic review provide an insight of the current role of flow cytometry in breast cancer and future horizons.

Keywords: aneuploidy; breast cancer; flow cytometry.

Publication types

Review