Posterior reversible encephalopathy syndrome in a melanoma patient with dabrafenib and trametinib treatment following immunotherapy

Maria-Ioanna Stefanou; Irina Gepfner-Tuma; Cornelia Brendle; Markus Kowarik; Andreas Meiwes; Thomas Eigentler; Alisa Müller; Claus Garbe; Ulf Ziemann; Ghazaleh Tabatabai; Andrea Forschner

doi:10.1111/ddg.13991

Posterior reversible encephalopathy syndrome in a melanoma patient with dabrafenib and trametinib treatment following immunotherapy

J Dtsch Dermatol Ges. 2020 Feb;18(2):136-139. doi: 10.1111/ddg.13991. Epub 2019 Dec 9.

Authors

Maria-Ioanna Stefanou^{1

2

3}, Irina Gepfner-Tuma^{1

2

3}, Cornelia Brendle^{1

4}, Markus Kowarik^{1

2

3}, Andreas Meiwes^{5

6}, Thomas Eigentler^{5

6}, Alisa Müller^{5

6}, Claus Garbe^{5

6}, Ulf Ziemann^{1

2

3}, Ghazaleh Tabatabai^{1

2

3}, Andrea Forschner^{5

6}

Affiliations

¹ Center for CNS Tumors, Comprehensive Cancer Center Tübingen-Stuttgart, Tübingen, Germany.
² Department of Neurology & Stroke, University Hospital Tübingen, Tübingen, Germany.
³ Hertie-Institute for Clinical Brain Research, Eberhard-Karls University of Tübingen, Tübingen, Germany.
⁴ Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
⁵ Center for Dermato-Oncology, Comprehensive Cancer Center Tübingen-Stuttgart, Tübingen, Germany.
⁶ Department of Dermatology, University Hospital Tübingen, Tübingen, Germany.

PMID: 31814289
DOI: 10.1111/ddg.13991

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adult
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Female
Humans
Imidazoles / adverse effects*
Immunotherapy / adverse effects
Ipilimumab / adverse effects
Melanoma / drug therapy*
Nivolumab / adverse effects
Oximes / adverse effects*
Posterior Leukoencephalopathy Syndrome / etiology*
Pyridones / adverse effects*
Pyrimidinones / adverse effects*
Skin Neoplasms / drug therapy*

Substances

Imidazoles
Ipilimumab
Oximes
Pyridones
Pyrimidinones
Nivolumab
trametinib
dabrafenib