Islet amyloid polypeptide: identification and chromosomal localization of the human gene

FEBS Lett. 1988 Nov 7;239(2):227-32. doi: 10.1016/0014-5793(88)80922-0.

Abstract

Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its carboxy-terminus is probably amidated. The predicted normally occurring IAPP is identical to the reported polypeptides isolated from pancreatic amyloid, except for the amidated carboxy-terminus. IAPP specific polyadenylated RNAs of 1.6 kb and 2.1 kb are present in human insulinoma RNA. The human IAPP gene is located on chromosome 12.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amyloid / genetics*
  • Base Sequence
  • Blotting, Northern
  • Blotting, Southern
  • Chromosome Mapping
  • Chromosomes, Human, Pair 12*
  • Genes*
  • Humans
  • Islet Amyloid Polypeptide
  • Molecular Sequence Data
  • Nucleic Acid Hybridization

Substances

  • Amyloid
  • Islet Amyloid Polypeptide