Metronomic Maintenance Therapy for Rhabdomyosarcoma

Abstract

In a recent article, Bisogno et al. reported in a randomized trial that addition of metronomic maintenance therapy (MMT) with vinorelbine plus cyclophosphamide for children with rhabdomyosarcoma resulted in a significant increase in overall and event-free survival. Although the mechanism of action remains to be fully elucidated, this study paves the way for further evaluation of MMT as a potential therapeutic strategy in pediatric patients with high-risk disease.

Keywords: angiogenesis; chemotherapy; immunity; maintenance; metronomic; microenvironment; rhabdomyosarcoma.