Recent progress in the development of organometallics for the treatment of cancer

Curr Opin Chem Biol. 2020 Jun:56:28-34. doi: 10.1016/j.cbpa.2019.11.001. Epub 2019 Dec 5.

Abstract

From their early successes in medicine, organometallic compounds continue to attract interest as potential chemotherapeutics to treat a range of diseases. Here, we show from recent literature selected largely from the last two years that organometallics offer unique opportunities in medicine and, increasingly, a mechanistic-based approach is applied to their development, which has not always been the case.

Keywords: Bioinorganic chemistry; Bioorganometallic chemistry; Chemotherapy; Metallodrugs.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Chromatin / chemistry
  • Combined Modality Therapy
  • Dose-Response Relationship, Drug
  • Gold / chemistry
  • Humans
  • Models, Molecular
  • Neoplasms / therapy*
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / pharmacology
  • Photochemotherapy
  • Platinum / chemistry*
  • Ruthenium / chemistry*
  • Silver / chemistry

Substances

  • Antineoplastic Agents
  • Chromatin
  • Organometallic Compounds
  • Silver
  • Platinum
  • Gold
  • Ruthenium