Identification of inhibitors of the immunosuppressive enzyme IL4I1

Bioorg Chem. 2020 Jan:94:103463. doi: 10.1016/j.bioorg.2019.103463. Epub 2019 Nov 23.
No abstract available

Keywords: Cancer therapy; Immunosuppressive enzymes; Inhibitors; Phenylalanine derivatives.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Immunosuppressive Agents / chemical synthesis
  • Immunosuppressive Agents / chemistry
  • Immunosuppressive Agents / pharmacology*
  • L-Amino Acid Oxidase / antagonists & inhibitors*
  • L-Amino Acid Oxidase / metabolism
  • Molecular Structure
  • Phenylalanine / chemical synthesis
  • Phenylalanine / chemistry
  • Phenylalanine / pharmacology*
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • Immunosuppressive Agents
  • Phenylalanine
  • IL4I1 protein, human
  • L-Amino Acid Oxidase