Human adenoviruses (HAdVs) are common pathogens associated with a wide variety of respiratory, ocular, and gastrointestinal diseases. To achieve its effective lytic mode of replication, HAdVs have to reprogram host-cell gene expression and fine-tune viral gene expression in a temporal manner. In two decades, omics revolution has advanced our knowledge about the HAdV and host-cell interplay at the RNA and protein levels. This review summarizes the current knowledge from large-scale datasets on how HAdV infections adjust coding and noncoding RNA expression, as well as how they reprogram host-cell proteome during the lytic course of infection.
Keywords: HAdV infection; RNA-Seq; SILAC-MS; lncRNA; miRNA; mivaRNA; proteomics; regulation of host-cell gene expression; transcriptomics; virus-host interaction.
© 2019 Federation of European Biochemical Societies.