Outbreak of an Uncommon Rifampin-resistant blaNDM-1Citrobacter amalonaticus Strain in a Digestive Rehabilitation Center: The Putative Role of Rifaximin

Clin Infect Dis. 2020 Aug 22;71(5):1331-1333. doi: 10.1093/cid/ciz1172.

Abstract

We describe a sudden 2-week outbreak due to a blaNDM-1Citrobacter amalonaticus strain in a 22-bed digestive rehabilitation center. Three of the 5 colonized patients received long-term rifaximin treatment to prevent hepatic encephalopathy. The strains were genotypically identical, phenotypically resistant to rifampin, and harbored arr-3, a rifampin adenosine diphosphate-ribosyl transferase.

Keywords: Citrobacter; rifaximin; CPE; NDM; rifampin.

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Anti-Bacterial Agents* / therapeutic use
  • Disease Outbreaks
  • Humans
  • Microbial Sensitivity Tests
  • Rehabilitation Centers
  • Rifampin* / pharmacology
  • Rifaximin

Substances

  • Anti-Bacterial Agents
  • Rifaximin
  • Rifampin