Sensing the Environment: Extracellular Lactate Levels Control Adult Neurogenesis

Valentina Scandella; Marlen Knobloch

doi:10.1016/j.stem.2019.11.008

Sensing the Environment: Extracellular Lactate Levels Control Adult Neurogenesis

Cell Stem Cell. 2019 Dec 5;25(6):729-731. doi: 10.1016/j.stem.2019.11.008.

Authors

Valentina Scandella¹, Marlen Knobloch²

Affiliations

¹ Department of Physiology, University of Lausanne, 1005 Lausanne, Switzerland.
² Department of Physiology, University of Lausanne, 1005 Lausanne, Switzerland. Electronic address: marlen.knobloch@unil.ch.

PMID: 31809733
DOI: 10.1016/j.stem.2019.11.008

Abstract

Metabolism has emerged as a key player for stem cell behavior; however, the role of metabolism in the microenvironment remains poorly understood. In this issue of Cell Stem Cell, Wang et al. (2019) show that brain endothelial cells directly affect adult neural stem cells and maintain a healthy metabolic environment by regulating lactate levels.

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MeSH terms

Adult
Brain
Endothelial Cells*
Hippocampus
Homeostasis
Humans
Lactic Acid*
Neurogenesis

Substances

Lactic Acid