LncRNA GATA6-AS Promotes Cancer Cell Proliferation and Inhibits Apoptosis in Glioma by Downregulating lncRNA TUG1

Cancer Biother Radiopharm. 2019 Dec;34(10):660-665. doi: 10.1089/cbr.2019.2830.

Abstract

Background: Long noncoding RNA (lncRNA) GATA6-AS regulates the growth of endothelial cells, indicating its involvement in human diseases. The present study aimed to investigate the roles of GATA6-AS in glioma. Results: GATA6-AS was significantly upregulated in glioma. GATA6-AS levels in plasma was positively and significantly correlated with its expression levels in glioma tissues. TUG1 was significantly downregulated in glioma and was inversely correlated with GATA6-AS. GATA6-AS overexpression led to TUG1 downregulation, whereas TUG1 overexpression failed to significantly affect GATA6-AS. GATA6-AS overexpression promoted glioma cell proliferation and inhibited apoptosis, TUG1 overexpression inhibited cell proliferation and attenuated the effects of GATA6-AS overexpression. Conclusions: Therefore, lncRNA GATA6-AS affects cell proliferation and apoptosis and regulates TUG1 expression in glioma.

Keywords: apoptosis; glioma; lncRNA GATA6-AS; lncRNA TUG1; proliferation.

MeSH terms

  • Adult
  • Aged
  • Apoptosis / physiology
  • Cell Line, Tumor
  • Cell Proliferation / physiology
  • Down-Regulation
  • Female
  • GATA6 Transcription Factor / genetics*
  • GATA6 Transcription Factor / metabolism
  • Glioma / blood
  • Glioma / genetics*
  • Glioma / metabolism
  • Glioma / pathology
  • Humans
  • Male
  • Middle Aged
  • RNA, Antisense / blood
  • RNA, Antisense / genetics*
  • RNA, Antisense / metabolism
  • RNA, Long Noncoding / antagonists & inhibitors
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / metabolism
  • Transfection
  • Up-Regulation

Substances

  • GATA6 Transcription Factor
  • GATA6 protein, human
  • RNA, Antisense
  • RNA, Long Noncoding
  • TUG1 long noncoding RNA, human