Abstract
Here we report the design and synthesis of a chlorambucil-alkynyl (CHL-CCH) ligand, mononuclear gold(i) complex K[(CHL-CC)AuCl], 1, and heteronuclear complex (CHL-CC)Au(μ2-η2-CS3)Ti(η5-Cp)2, 2 for renal cancer. Complex 2 is significantly more cytotoxic than complex 1 and cisplatin against renal cancer cells with a high selectivity index value. The mechanism of action of these complexes against renal cancer cells was studied in detail by experimental and computational methods.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Cell Line, Tumor
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Chlorambucil / analogs & derivatives*
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Chlorambucil / chemical synthesis
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Chlorambucil / pharmacology*
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Coordination Complexes / chemical synthesis
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Coordination Complexes / pharmacology*
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Density Functional Theory
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Drug Design
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology*
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Gold / chemistry
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Humans
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Kidney Neoplasms / drug therapy
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Models, Chemical
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Molecular Docking Simulation
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Thioredoxin-Disulfide Reductase / antagonists & inhibitors*
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Titanium / chemistry
Substances
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Antineoplastic Agents
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Coordination Complexes
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Enzyme Inhibitors
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Chlorambucil
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Gold
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Titanium
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Thioredoxin-Disulfide Reductase