A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging

Chem Commun (Camb). 2019 Dec 19;56(2):301-304. doi: 10.1039/c9cc07750b.

Abstract

Bioimaging has revolutionized modern medicine, and nanotechnology can offer further specific and sensitive imaging. We report here an amphiphilic dendrimer able to self-assemble into supramolecular nanomicelles for effective tumor detection using SPECT radioimaging. This highlights the promising potential of supramolecular dendrimer platforms for biomedical imaging.

MeSH terms

  • Adenocarcinoma / diagnostic imaging
  • Animals
  • Cell Line, Tumor
  • Chelating Agents / chemical synthesis
  • Chelating Agents / chemistry
  • Dendrimers / chemical synthesis
  • Dendrimers / chemistry*
  • Heterocyclic Compounds, 1-Ring / chemical synthesis
  • Heterocyclic Compounds, 1-Ring / chemistry
  • Humans
  • Indium
  • Indium Radioisotopes
  • Mice
  • Micelles
  • Nanostructures / chemistry*
  • Pancreatic Neoplasms / diagnostic imaging
  • Radioisotopes
  • Surface-Active Agents / chemical synthesis
  • Surface-Active Agents / chemistry*
  • Tomography, Emission-Computed, Single-Photon / methods

Substances

  • Chelating Agents
  • Dendrimers
  • Heterocyclic Compounds, 1-Ring
  • Indium Radioisotopes
  • Indium-115
  • Micelles
  • Radioisotopes
  • Surface-Active Agents
  • Indium
  • 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
  • Indium-111