The historical hill-site zone of Prosecco's wine production was recognised as a UNESCO World Heritage Site. This area is part of the province of Treviso, an area where in recent years many lands have been occupied by the viticulture to produce this type of wine, due to a growing demand of prosecco, especially on international markets. Currently viticulture occupies 31% of the total agricultural area of the province. This is determining an important alteration of the landscape of the area, with serious loss of biodiversity. Even more, this intensive cultivation requires the use of many pesticides (in 2018, 4,622 tons were sold, equivalent to more than 36 kg per hectare of arable land), that are harmful to the health of the population. They can cause acute effects by inhalation or contact during the treatment of the vines, and chronic effects for the continuous intake of small doses through contaminated waters. To safeguard the environment and health, two actions are needed: to reduce the use of pesticides by promoting organic production; to restore biodiversity by promoting other crops besides the vineyards. Our hope is that belonging to the UNESCO heritage world list favours these actions.