Draft Genome Sequences of Mycobacterium tuberculosis Clinical Isolates from the Ural Region of Russia That Carry the pks15/1 Gene

Kirill V Shur; Natalia V Zakharevich; Natalia I Akimova; Roman A Yunes; Svetlana G Frolova; Dmitry A Maslov; Valery N Danilenko

doi:10.1128/MRA.01126-19

Draft Genome Sequences of Mycobacterium tuberculosis Clinical Isolates from the Ural Region of Russia That Carry the pks15/1 Gene

Microbiol Resour Announc. 2019 Dec 5;8(49):e01126-19. doi: 10.1128/MRA.01126-19.

Authors

Kirill V Shur¹, Natalia V Zakharevich², Natalia I Akimova², Roman A Yunes², Svetlana G Frolova², Dmitry A Maslov², Valery N Danilenko²

Affiliations

¹ Vavilov Institute of General Genetics Russian Academy of Sciences, Moscow, Russia shurkirill@gmail.com.
² Vavilov Institute of General Genetics Russian Academy of Sciences, Moscow, Russia.

Abstract

Here, we report the draft genome sequences of 15 Mycobacterium tuberculosis isolates of the Beijing-B0/W-148 sublineage that carry a 7-bp insertion within the pks15 gene, which leads to the synthesis of Pks15/1 fusion protein. Pks15/1 is involved in phenolglycolipid synthesis and biofilm formation, thus potentially contributing to the B0/W-148 lineage's enhanced virulence and drug resistance.