Chemical design and bioefficacy screening of new insect growth regulators as potential insecticidal agents against Spodoptera littoralis (Boisd.)

Antar A Abdelhamid; M M Elwassimy; Safwat A Aref; Mohamed A Gad

doi:10.1016/j.btre.2019.e00394

Chemical design and bioefficacy screening of new insect growth regulators as potential insecticidal agents against Spodoptera littoralis (Boisd.)

Biotechnol Rep (Amst). 2019 Nov 12:24:e00394. doi: 10.1016/j.btre.2019.e00394. eCollection 2019 Dec.

Authors

Antar A Abdelhamid¹, M M Elwassimy¹, Safwat A Aref², Mohamed A Gad²

Affiliations

¹ Department of Chemistry, Faculty of Science, Sohag University, 82524 Sohag, Egypt.
² Research Institute of Plant Protection, Agriculture Research Center, 12112 Giza, Egypt.

Abstract

The 13 new compounds were chemically synthesized and their spectroscopic analysis was done to determine their chemical structure. All the compounds were screened for their insecticidal potential against Spodoptera littoralis (Boisd.). Among the tested compounds, the compound 13 was found to be the most potent. It displayed one fold more activity than a reported insect growth regulator, fenoxycarb. The other target compounds demonstrated weak to strong toxicological activities against Spodoptera littoralis (Boisd.).

Keywords: Fenoxycarb; Insect growth regulators; Spodoptera littoralis(Boisd); Toxicity.