An epidemiology report for primary central nervous system tumors in adolescents and young adults: a nationwide population-based study in France, 2008-2013

Sam Ng; Sonia Zouaoui; Faiza Bessaoud; Valérie Rigau; Alexandre Roux; Amélie Darlix; Fabienne Bauchet; Hélène Mathieu-Daudé; Brigitte Trétarre; Dominique Figarella-Branger; Johan Pallud; Didier Frappaz; Thomas Roujeau; Luc Bauchet

doi:10.1093/neuonc/noz227

An epidemiology report for primary central nervous system tumors in adolescents and young adults: a nationwide population-based study in France, 2008-2013

Neuro Oncol. 2020 Jun 9;22(6):851-863. doi: 10.1093/neuonc/noz227.

Authors

Sam Ng¹, Sonia Zouaoui¹, Faiza Bessaoud², Valérie Rigau³, Alexandre Roux^{4

5}, Amélie Darlix^{6

7

8}, Fabienne Bauchet⁸, Hélène Mathieu-Daudé^{8

9}, Brigitte Trétarre², Dominique Figarella-Branger^{10

11}, Johan Pallud^{4

5}, Didier Frappaz¹², Thomas Roujeau¹, Luc Bauchet^{1

8

13}

Affiliations

¹ Department of Neurosurgery, Gui de Chauliac Hospital, University Hospital Center (CHU) Montpellier, Montpellier University Medical Center, Montpellier, France.
² Tumor Registry of the Hérault, Institut du Cancer de Montpellier, Montpellier, France.
³ Department of Neuropathology, Gui de Chauliac Hospital, CHU Montpellier, Montpellier University Medical Center, Montpellier, France.
⁴ Department of Neurosurgery, University Hospital Group Paris, Sainte-Anne Hospital, Paris, France.
⁵ Paris Descartes University, Imaging Biomarkers of Brain Disorders, Institute of Psychiatry and Neurosciences of Paris, Paris, France.
⁶ Department of Medical Oncology, Institut du Cancer de Montpellier, Montpellier, France.
⁷ University of Montpellier, Montpellier, France.
⁸ Neuro-Oncology Group of Languedoc Roussillon, Institut du Cancer de Montpellier, Montpellier, France.
⁹ Department of Medical Informatics, Institut du Cancer de Montpellier, Montpellier, France.
¹⁰ Aix-Marseille University, National Center for Scientific Research, Institute of Neuro-Physiopathology, Marseille, France.
¹¹ Department of Pathology and Neuropathology, Timone Hospital, Marseille, France.
¹² Institute of Pediatric Onco-Hematology, Lyon, France.
¹³ National Institute of Health and Medical Research unit 1051, Montpellier, France.

Abstract

Background: Primary central nervous system tumors (PCNST) among adolescents and young adults (AYA, 15-39 y) have rarely been reported. We present a nationwide report of PCNST histologically confirmed in the French AYA population between 2008 and 2013.

Methods: Patients were identified through the French Brain Tumor Database (FBTDB), a national dataset that includes prospectively all histologically confirmed cases of PCNST in France. Patients aged 15 to 39 years with histologically confirmed PCNST diagnosed between 2008 and 2013 were included. For each of the 143 histological subtypes of PCNST, crude rates, sex, surgery, and age distribution were provided. To enable international comparisons, age-standardized incidence rates were adjusted to the world-standard, European, and USA populations.

Results: For 6 years, 9661 PCNST (males/females: 4701/4960) were histologically confirmed in the French AYA population. The overall crude rate was 8.15 per 100 000 person-years. Overall, age-standardized incidence rates were (per 100 000 person-years, population of reference: world/Europe/USA): 7.64/8.07/8.21, respectively. Among patients aged 15-24 years, the crude rate was 5.13 per 100 000. Among patients aged 25-39 years, the crude rate was 10.10 per 100 000. Age-standardized incidence rates were reported for each of the 143 histological subtypes. Moreover, for each histological subtype, data were detailed by sex, age, type of surgery (surgical resection or biopsy), and cryopreserved samples.

Conclusion: These data represent an exhaustive report of all histologically confirmed cases of PCNST with their frequency and distribution in the French AYA population in 2008-2013. For the first time in this age group, complete histological subtypes and rare tumor identification are detailed.

Keywords: adolescent and young adult; brain tumor; epidemiology; neuro-oncology; neuropathology; neurosurgery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Age Distribution
Brain Neoplasms* / epidemiology
Central Nervous System Neoplasms* / epidemiology
Europe
Female
France / epidemiology
Humans
Incidence
Male
Young Adult