Laxative use among older adults with intellectual disability: a cross-sectional observational study

Int J Clin Pharm. 2020 Feb;42(1):89-99. doi: 10.1007/s11096-019-00942-z. Epub 2019 Dec 2.

Abstract

Background: Chronic constipation is a prevalent issue in older people with intellectual disabilities and may have a significant negative impact on quality of life. The use of laxatives have not been adequately studied in this population.

Objective: To examine laxatives in relation to prevalence, pattern, dosage, reported indication and correlates.

Setting: Older people with intellectual disabilities who live independently, in community group homes or residential care in Ireland.

Method: Data was extracted from wave 2 (2013/2014) of the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA). Descriptive statistics, bivariate analyses and multiple logistic regression were carried out. Laxative use was analysed using two indicators for chronic constipation, reported doctor's diagnosis of constipation and Rome III criteria.

Main outcome measure: Laxative use.

Results: Among the cohort n = 677, chronic constipation was reported by 38.5% (n = 257). In total 41.5% (n = 281) reported 431 laxatives (mean ± 1.53 ± 0.74), with 74.3% (n = 209) of those with laxative use reporting chronic constipation. There were 40% (n = 113) who took 2 + laxatives, within which, 60% (n = 67) were using a combination from same laxative class. Reporting chronic constipation, living in residential care, exposure to anticholinergics and receiving soft/liquidized food were significantly associated with laxative use.

Conclusion: Chronic constipation and laxative use were highly prevalent in this study of older adults with intellectual disabilities. The treatment of constipation appeared to be unsystematic. Intra-class laxative use was frequent. There is a need for evidence-based treatment guidelines developed especially for people with intellectual disabilities to provide effective, quality care.

Keywords: Constipation; Intellectual disability; Ireland; Laxative use; Older people; Treatment guidelines.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Aged
  • Cohort Studies
  • Constipation / drug therapy*
  • Constipation / epidemiology*
  • Constipation / psychology
  • Cross-Sectional Studies
  • Female
  • Humans
  • Intellectual Disability / drug therapy*
  • Intellectual Disability / epidemiology*
  • Intellectual Disability / psychology
  • Ireland / epidemiology
  • Laxatives / administration & dosage*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Random Allocation

Substances

  • Laxatives