The impact of HIV central nervous system persistence on pathogenesis

Bruce J Brew; Stephanie L Barnes

doi:10.1097/QAD.0000000000002251

The impact of HIV central nervous system persistence on pathogenesis

AIDS. 2019 Dec 1:33 Suppl 2:S113-S121. doi: 10.1097/QAD.0000000000002251.

Authors

Bruce J Brew^{1

2

3}, Stephanie L Barnes¹

Affiliations

¹ Departments of Neurology and HIV Medicine, St. Vincent's Hospital, Darlinghurst, Sydney.
² Applied Neurosciences Program, Peter Duncan Neuroscience Research Unit, St. Vincent's Centre for Applied Medical Research, Darlinghurst.
³ Faculties of Medicine, UNSW Australia, and University of Notre Dame Sydney, New South Wales, Australia.

PMID: 31790377
DOI: 10.1097/QAD.0000000000002251

Abstract

: The persistence of HIV in the central nervous system is somewhat controversial particularly in the context of HIV viral suppression from combined antiretroviral therapy. Further, its significance in relation to HIV pathogenesis in the context of HIV-associated neurocognitive disorders, systemic HIV pathogenesis, and eradication in general, but especially from the brain, are even more contentious. This review will discuss each of these aspects in detail, highlighting new data, particularly from recent conference presentations.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

AIDS Dementia Complex / drug therapy
Anti-HIV Agents / therapeutic use
Antiretroviral Therapy, Highly Active
Brain / pathology
Brain / virology
Central Nervous System / pathology
Central Nervous System / virology*
Central Nervous System Diseases / pathology
Central Nervous System Diseases / virology*
HIV / pathogenicity*
HIV Infections / epidemiology
HIV Infections / pathology*
Humans
Magnetic Resonance Imaging
RNA, Viral / blood

Substances

Anti-HIV Agents
RNA, Viral