Frailty and Neurocognitive Impairment: Impacts on Quality of Life in HIV

Anna A Rubtsova; Samir Sabbag; Erin Sundermann; Annie L Nguyen; Ronald J Ellis; David J Moore; Scott Letendre; Dilip V Jeste; María J Marquine

doi:10.1097/JNC.0000000000000142

Frailty and Neurocognitive Impairment: Impacts on Quality of Life in HIV

J Assoc Nurses AIDS Care. 2020 May-Jun;31(3):290-300. doi: 10.1097/JNC.0000000000000142.

Authors

Anna A Rubtsova¹, Samir Sabbag, Erin Sundermann, Annie L Nguyen, Ronald J Ellis, David J Moore, Scott Letendre, Dilip V Jeste, María J Marquine

Affiliation

¹ Anna A. Rubtsova, PhD, MA, MSc, is an Assistant Research Professor, Department of Behavioral Sciences and Health Education, Emory University Rollins School of Public Health, Atlanta, Georgia, USA. Samir Sabbag, MD, is an Assistant Professor, Department of Psychiatry, University of Miami, Miami, Florida, USA. Erin Sundermann, PhD, is an Assistant Project Scientist, Department of Psychiatry, University of California, San Diego, California, USA. Annie L. Nguyen, PhD, is an Assistant Professor, Department of Family Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA. Ronald J. Ellis, MD, PhD, is a Professor, Departments of Neuroscience and Psychiatry, University of California, San Diego, California, USA. David J. Moore, PhD, is an Associate Professor, Department of Psychiatry, University of California, San Diego, California, USA. Scott Letendre, MD, is a Professor, Department of Medicine, University of California, San Diego, California, USA. Dilip V. Jeste, MD, is a Distinguished Professor, Departments of Neuroscience and Psychiatry, University of California, San Diego, California, USA. María J. Marquine, PhD, is an Assistant Professor, Department of Psychiatry, University of California, San Diego, California, USA.

Abstract

Little is known about the effects of aging-related conditions on health-related quality of life (HRQOL) among people living with HIV (PLWH). The purpose of our study was to examine the independent effects of neurocognitive impairment (NCI) and frailty and the interactive effects with HIV serostatus on HRQOL. Our sample consisted of 121 adults (63 PLWH and 58 HIV-uninfected) participating in the Multi-Dimensional Successful Aging among HIV-Infected Adults study at the University of California, San Diego. HRQOL was measured with the Medical Outcome Study 36-Item Short Form Health Survey scale. We found that frailty was significantly associated with HRQOL (p < .001) in the overall sample, and this effect was significantly stronger for PLWH than HIV-uninfected adults. NCI was not significantly associated with HRQOL in our sample. Frailty may be a particularly important factor in HRQOL for PLWH, highlighting the need for prevention and intervention strategies to mitigate the risks for frailty.

Publication types

Observational Study
Research Support, N.I.H., Extramural

MeSH terms

Adult
Aged
Aging*
Antiretroviral Therapy, Highly Active
Comorbidity
Depression / psychology*
Female
Frailty*
HIV Infections / drug therapy
HIV Infections / epidemiology
HIV Infections / psychology*
Humans
Male
Middle Aged
Neurocognitive Disorders / diagnosis
Neurocognitive Disorders / epidemiology*
Quality of Life / psychology*
Sickness Impact Profile

Abstract

Publication types

MeSH terms

Grants and funding