Long noncoding RNA IRAIN acts as tumor suppressor via miR-125b in multiple myeloma

Yanxia Jiang; Jian Chen; Guoan Chen

doi:10.3892/ol.2019.11012

Long noncoding RNA IRAIN acts as tumor suppressor via miR-125b in multiple myeloma

Oncol Lett. 2019 Dec;18(6):6787-6794. doi: 10.3892/ol.2019.11012. Epub 2019 Oct 21.

Authors

Yanxia Jiang¹, Jian Chen¹, Guoan Chen¹

Affiliation

¹ Hematology Department, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, P.R. China.

Abstract

Long noncoding RNAs (lncRNAs) are aberrantly expressed in a variety of cancer types. The lncRNA IGF1R antisense imprinted non-protein coding RNA (IRAIN) is associated with various cancer types, yet the role of IRAIN in multiple myeloma (MM) progression remains unclear. In the present study it was identified that IRAIN may act as a tumor suppressor in MM, whilst microRNA (miR)-125b may promote tumorigenesis. Downregulation of IRAIN significantly increased the expression of miR-125b. Furthermore, by using dual-luciferase reporter assays, IRAIN was identified as a target of miR-125b. Knockdown of IRAIN promoted MM cell proliferation in vitro. Thus, expression levels of IRAIN may be used to predict the clinical prognosis of patients with MM and may be a novel therapeutic target for treating MM.

Keywords: IGF1R antisense imprinted non-protein coding RNA; cell apoptosis; cell migration; cell proliferation; metastasis; microRNA-125b; multiple myeloma.