Severe underlying liver diseases and high mortality associated with Laribacter hongkongensis bacteremia

Derek L L Hung; Jade L L Teng; Jordan Y H Fong; Qiong Wang; Zhixin Chen; Ami M Y Fung; Susanna K P Lau; Patrick C Y Woo

doi:10.1016/j.diagmicrobio.2019.114948

Severe underlying liver diseases and high mortality associated with Laribacter hongkongensis bacteremia

Diagn Microbiol Infect Dis. 2020 Feb;96(2):114948. doi: 10.1016/j.diagmicrobio.2019.114948. Epub 2019 Nov 21.

Authors

Derek L L Hung¹, Jade L L Teng², Jordan Y H Fong¹, Qiong Wang¹, Zhixin Chen¹, Ami M Y Fung¹, Susanna K P Lau³, Patrick C Y Woo⁴

Affiliations

¹ Department of Microbiology, The University of Hong Kong, Hong Kong, China.
² Department of Microbiology, The University of Hong Kong, Hong Kong, China; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China.
³ Department of Microbiology, The University of Hong Kong, Hong Kong, China; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong, China. Electronic address: skplau@hku.hk.
⁴ Department of Microbiology, The University of Hong Kong, Hong Kong, China; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong, China. Electronic address: pcywoo@hku.hk.

PMID: 31787408
DOI: 10.1016/j.diagmicrobio.2019.114948

Abstract

We characterized a strain of Laribacter hongkongensis isolated from the blood of a patient with fatal sepsis, who had alcoholic cirrhosis with ascites and portal hypertension. L. hongkongensis bacteremia is associated with underlying liver diseases (P < 0.001) and mortality (P < 0.05), whereas L. hongkongensis gastroenteritis is associated with recent travel history (P < 0.05).

Keywords: Bacteremia; Laribacter hongkongensis; Liver diseases; Mortality.

Publication types

Case Reports
Review

MeSH terms

Bacteremia / complications*
Bacteremia / diagnosis*
Bacteremia / microbiology
Bacterial Infections / complications*
Bacterial Infections / diagnosis*
Bacterial Infections / microbiology
Betaproteobacteria* / classification
Betaproteobacteria* / genetics
Biomarkers
Fatal Outcome
Humans
Liver Diseases / complications*
Liver Diseases / diagnosis*
Phylogeny
RNA, Bacterial
RNA, Ribosomal, 16S
Severity of Illness Index
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

Biomarkers
RNA, Bacterial
RNA, Ribosomal, 16S

Supplementary concepts

Laribacter hongkongensis