A consideration of physiological regulation from the perspective of Bayesian enactivism

Abstract

How the animal regulates its internal environment is a central question in physiology. In recent years, the account of biological functions known as Bayesian enactivism has been extended from neuroscience to address processes of physiological regulation. Enactivism understands sensory action cycles of perception and behaviour to entail expectations of the causes of sensations received from the environment. Enactivism is Bayesian in that the organism strives to update expectations to better match the sensations it experiences through actions. The review starts with a brief examination of the historical development of the concepts of homeostasis, homeorhesis and allostasis. To better align the historical concepts of physiological regulation with Bayesian enactivism it is suggested that homeorhesis and allostasis function as opposing effectors modulating, respectively, robustness and plasticity of phenotype to render homeostatic balance of the animal with its changing environment. In this formulation, the expectations of the environment embedded within the form and functions of the animal that develop under homeorhetic control during morphogenesis and morphostasis are updated by allostasis to better match the animal's phenotype with its contemporary environment. Just as morphogens shape development and persistence of anatomical form during morphogenesis and morphostasis, anticipatory behaviours can be understood to structure the animal's pattern of environmental engagement in a manner that shapes the development and persistence of homeostasis. Further empirical and theoretical analyses should help clarify whether homeorhesis and allostasis are aspects of a common underlying process or are opposing effectors mediating a Bayesian dialogue between expectation and experience.

Keywords: Allostasis; Homeorhesis; Homeostasis; Morphogenetic field; Plasticity; Robustness.