Diagnosis for MDD in modern psychiatry has developed for decades based on long traceable historic efforts on conceptualizing the illness. This article reviews the historical background of current diagnostic framework for MDD, diagnostic criteria and two newly added specifiers ("with anxious distress" and "with mixed features" specifiers) of MDD in the DSM-5, the most influential diagnostic instrument in the world, as well as problems and limitations of symptom-based diagnosis for sake of better understanding about the inter-relationship between diagnostic criteria and MDD.
Keywords: Criterion symptoms; Diagnosis; Major depressive disorder; Specifiers.