A New Host Factor Essential for Chikungunya Virus

Barbara S Schnierle

doi:10.1016/j.tim.2019.11.002

A New Host Factor Essential for Chikungunya Virus

Trends Microbiol. 2020 Jan;28(1):2-4. doi: 10.1016/j.tim.2019.11.002. Epub 2019 Nov 25.

Author

Barbara S Schnierle¹

Affiliation

¹ Paul-Ehrlich-Institut, Department of Virology, Paul-Ehrlich Strass 51-59, 63225 Langen, Germany. Electronic address: Barbara.Schnierle@pei.de.

PMID: 31780232
DOI: 10.1016/j.tim.2019.11.002

Abstract

FHL1 has been identified as a host protein that is essential for chikungunya virus (CHIKV) replication. FHL1 interacts with the chikungunya non-structural protein 3, which is thought to recruit cellular proteins to the viral replication complex. Inhibition of this interaction is a promising target for drug development.

Keywords: FHL1; alphavirus; chikungunya virus; non-structural protein 3.

MeSH terms

Alphavirus
Animals
Chikungunya Fever / virology*
Chikungunya virus / physiology*
Humans
Intracellular Signaling Peptides and Proteins
LIM Domain Proteins
Mice, Knockout
Muscle Proteins
RNA, Viral
Viral Nonstructural Proteins / chemistry
Virus Replication / physiology*

Substances

Intracellular Signaling Peptides and Proteins
LIM Domain Proteins
Muscle Proteins
RNA, Viral
Viral Nonstructural Proteins