Chitosan polymer complex derived nanocomposite (AgNPs/NSC) for electrochemical non-enzymatic glucose sensor

Naif Khalaf; Tansir Ahamad; Mu Naushad; Noorah Al-Hokbany; Sameerah I Al-Saeedi; Sultanah Almotairi; Saad M Alshehri

doi:10.1016/j.ijbiomac.2019.11.193

Chitosan polymer complex derived nanocomposite (AgNPs/NSC) for electrochemical non-enzymatic glucose sensor

Int J Biol Macromol. 2020 Mar 1:146:763-772. doi: 10.1016/j.ijbiomac.2019.11.193. Epub 2019 Nov 26.

Authors

Naif Khalaf¹, Tansir Ahamad¹, Mu Naushad¹, Noorah Al-Hokbany¹, Sameerah I Al-Saeedi², Sultanah Almotairi¹, Saad M Alshehri³

Affiliations

¹ Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
² Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
³ Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. Electronic address: alshehri@ksu.edu.sa.

PMID: 31778696
DOI: 10.1016/j.ijbiomac.2019.11.193

Abstract

N/S-doped carbon supported AgNPs has been synthesized at low-cost, and scalable method using silver complex of chitosan based polymer. The fabricated nanocomposites exhibited excellent electrocatalytic performance as a glucose sensor. Remarkably, the fabricated glucose sensor is exhibited an ultrahigh sensitivity of 35.22 mAmM^-1 cm^-2 with a very low detection limit (0.046 mM) and long-term durability (30 days). Under optimized conditions, a wide linear response was obtained from 5 μM to 3 mM with an excellent linear response (R² = 0.9940) was also obtained by AgNPs/NSC modified electrode. The presence of the heteroatom and AgNPs into the carbon matrix greatly enhances the selectivity for glucose over potential interferences in aqueous solution, with interfering agents. Overall, the present methodology demonstrates an efficient, robust, and aqueous-media-tolerable nanocomposite material as an electrochemical sensor and a potential alternative tool for the detection of glucose.

Keywords: Carbon matrix; Chitosan; Glucose; Raman; Silver nanoparticles.

MeSH terms

Biosensing Techniques / methods*
Carbon
Chitosan / chemistry*
Electrochemical Techniques / methods*
Electrochemistry
Electrodes
Formaldehyde / chemistry
Glucose / analysis*
Limit of Detection
Metal Nanoparticles / chemistry*
Nanocomposites / chemistry*
Polymers / chemistry*
Reproducibility of Results
Silver / chemistry*
Thiourea / chemistry

Substances

Polymers
Formaldehyde
Silver
Carbon
Chitosan
Thiourea
Glucose