Modeling the Evolution of Human Brain Development Using Organoids

Sydney Keaton Muchnik; Belen Lorente-Galdos; Gabriel Santpere; Nenad Sestan

doi:10.1016/j.cell.2019.10.041

Modeling the Evolution of Human Brain Development Using Organoids

Cell. 2019 Nov 27;179(6):1250-1253. doi: 10.1016/j.cell.2019.10.041.

Authors

Sydney Keaton Muchnik¹, Belen Lorente-Galdos¹, Gabriel Santpere², Nenad Sestan³

Affiliations

¹ Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA.
² Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA; Neurogenomics Group, Research Programme on Biomedical Informatics, Hospital del Mar Medical Research Institute, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address: gabrielsantperebaro@gmail.com.
³ Departments of Genetics, Psychiatry, and Comparative Medicine, Program in Cellular Neuroscience, Neurodegeneration and Repair, and Yale Child Study Center, Yale School of Medicine, New Haven, CT, USA. Electronic address: nenad.sestan@yale.edu.

Abstract

In a recent issue of Nature, Kanton et al. explore human brain evolution and development by profiling the single-cell transcriptomes and epigenomes of cerebral organoids derived from human, chimpanzee, and macaque stem cells. Their results reveal key molecular characteristics that differentiate humans and non-human primates at the earliest stages of brain development.

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MeSH terms

Animals
Brain
Genomics*
Humans
Organoids*
Pan troglodytes
Transcriptome

Abstract

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MeSH terms

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