Fast-Acting Black-Phosphorus-Assisted Depression Therapy with Low Toxicity

Adv Mater. 2020 Jan;32(2):e1906050. doi: 10.1002/adma.201906050. Epub 2019 Nov 28.

Abstract

A black phosphorus (BP)-nanosheet-based drug-delivery system containing a therapeutic drug (Fluoxetine, Flu) is synthesized. According to subsequent behavioral, biochemical, and electrophysiological analysis, BP-Flu, after irradiated with near-infrared light (808 nm), can significantly reduce the therapy time of depression. Meanwhile, the inherent biotoxicity of Flu is also alleviated.

Keywords: black phosphorus; depression; fluoxetine; near-infrared light; photothermal therapy.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Depression / drug therapy*
  • Depression / metabolism
  • Depression / physiopathology
  • Drug Carriers / chemistry*
  • Electrophysiological Phenomena / drug effects
  • Fluoxetine / chemistry*
  • Fluoxetine / pharmacology*
  • Fluoxetine / therapeutic use
  • Fluoxetine / toxicity
  • Kinetics
  • Mice
  • Phosphorus / chemistry*

Substances

  • Drug Carriers
  • Fluoxetine
  • Phosphorus