A rare case of gastric-type mucinous adenocarcinoma in a woman with Peutz-Jeghers syndrome

Yeorae Kim; Eun Yi Kim; Tae Jin Kim; Kyung Taek Lim; Ki Heon Lee; Yikyeong Chun; Kyeong A So

doi:10.5468/ogs.2019.62.6.474

A rare case of gastric-type mucinous adenocarcinoma in a woman with Peutz-Jeghers syndrome

Obstet Gynecol Sci. 2019 Nov;62(6):474-477. doi: 10.5468/ogs.2019.62.6.474. Epub 2019 Oct 11.

Authors

Yeorae Kim^{1

2}, Eun Yi Kim^{1

3}, Tae Jin Kim³, Kyung Taek Lim^{1

4}, Ki Heon Lee^{1

5}, Yikyeong Chun⁶, Kyeong A So³

Affiliations

¹ Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, College of Medicine, Dankook University, Seoul, Korea.
² Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seoul, Korea.
³ Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Korea.
⁴ Department of Obstetrics and Gynecology, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea.
⁵ CHA Gangnam Medical Center, CHA University, Seoul, Korea.
⁶ Department of Pathology, Cheil General Hospital & Women's Healthcare Center, College of Medicine, Dankook University, Seoul, Korea.

Abstract

Adenocarcinoma of the cervix is less common than squamous cell carcinoma. Minimal deviation adenocarcinoma (adenoma malignum) is considered an extremely well-differentiated variant of GAS. An association exists between GAS and Peutz-Jeghers syndrome, which is a rare autosomal dominant disorder characterized by mucocutaneous pigmentation and multiple hamartomatous polyps in the gastrointestinal tracts. The incidence of GAS in patients with Peutz-Jeghers syndrome is estimated to be 11-17%. We present a rare case of adenoma malignum, diagnosed using colposcopic biopsy in a woman with Peutz-Jeghers syndrome, which was histopathologically confirmed to be GAS after surgery.

Keywords: Adenocarcinoma; Peutz-Jeghers syndrome; Uterine cervical neoplasms.

Publication types

Case Reports