Clinical Characteristics of Active Tuberculosis Diagnosed After Starting Treatment for Latent Tuberculosis Infection

Andrew G Flynn; Kaylynn Aiona; Michelle K Haas; Randall Reves; Robert Belknap

doi:10.1093/cid/ciz1157

Clinical Characteristics of Active Tuberculosis Diagnosed After Starting Treatment for Latent Tuberculosis Infection

Clin Infect Dis. 2020 Aug 22;71(5):1320-1323. doi: 10.1093/cid/ciz1157.

Authors

Andrew G Flynn^{1

2}, Kaylynn Aiona³, Michelle K Haas^{2

3}, Randall Reves², Robert Belknap^{2

3}

Affiliations

¹ Department of Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.
² University of Colorado School of Medicine, Aurora, Colorado, USA.
³ Denver Health and Hospital Authority, Denver, Colorado, USA.

PMID: 31773132
DOI: 10.1093/cid/ciz1157

Abstract

Although rare, subclinical tuberculosis disease can be missed during evaluations for latent tuberculosis infection, and can manifest with symptoms during latent tuberculosis treatment. Among over 8000 patients treated for latent tuberculosis we found no evidence of acquired drug resistance, underscoring the safety of rifampin monotherapy for latent tuberculosis.

Keywords: drug-resistant tuberculosis; isoniazid; paradoxical reaction; rifampin.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Antitubercular Agents / therapeutic use
Humans
Isoniazid / therapeutic use
Latent Tuberculosis* / diagnosis
Latent Tuberculosis* / drug therapy
Rifampin / therapeutic use
Tuberculosis* / drug therapy

Substances

Antitubercular Agents
Isoniazid
Rifampin