Robust Optimization for Intensity Modulated Proton Therapy Plans with Multi-Isocenter Large Fields

Li Liao; Gino J Lim; Yupeng Li; Juan Yu; Narayan Sahoo; Heng Li; Michael Gillin; X Ronald Zhu; Anita Mahajan; Steven J Frank; David R Grosshans; Quynh-Nhu Nguyen; Daniel Gomez; Xiaodong Zhang

doi:10.14338/IJPT-16-00012.1

Robust Optimization for Intensity Modulated Proton Therapy Plans with Multi-Isocenter Large Fields

Int J Part Ther. 2016 Fall;3(2):305-311. doi: 10.14338/IJPT-16-00012.1. Epub 2016 Dec 30.

Authors

Li Liao¹, Gino J Lim¹, Yupeng Li², Juan Yu^{3

4}, Narayan Sahoo³, Heng Li³, Michael Gillin³, X Ronald Zhu³, Anita Mahajan⁵, Steven J Frank⁵, David R Grosshans⁵, Quynh-Nhu Nguyen⁵, Daniel Gomez⁵, Xiaodong Zhang³

Affiliations

¹ Department of Industrial Engineering, The University of Houston, Houston, TX, USA.
² Applied Research, Varian Medical Systems, Palo Alto, CA, USA.
³ Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁴ Maryland Proton Treatment Center, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.
⁵ Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Abstract

We have developed a robust optimization approach for intensity modulated proton therapy treatment plans with multi-isocenter large fields. The method creates a low-gradient field dose in the junction regions to mitigate the impact caused by misalignment errors and is more efficient than the conventional junction shifting technique.

Keywords: craniospinal irradiation; intensity modulated proton therapy; mesothelioma; optimization.