Abstract
Primary biliary cholangitis and primary sclerosing cholangitis are rare diseases affecting the bile ducts and the liver. The limited knowledge of their pathogenesis leads to limited therapeutic options. Nevertheless, the landscape of novel therapies for these cholangiopathies is now rapidly changing, providing new treatment opportunities for patients and clinicians involved in their care. The aim of this review is to summarize the evidence of novel molecules under investigation for primary biliary cholangitis and primary sclerosing cholangitis and to discuss how they can potentially change current treatment paradigms.
Keywords:
Bile acids; FXR agonists; Fibrates; Gut–liver axis; Microbiome; Precision medicine; Primary biliary cholangitis; Primary sclerosing cholangitis.
Copyright © 2019 Fundación Clínica Médica Sur, A.C. Published by Elsevier España, S.L.U. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Abatacept / therapeutic use
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Anti-Bacterial Agents / therapeutic use*
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Azetidines / therapeutic use
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Benzothiazoles / therapeutic use
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Bezafibrate / therapeutic use
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Chalcones / therapeutic use
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Chenodeoxycholic Acid / analogs & derivatives
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Chenodeoxycholic Acid / therapeutic use
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Cholagogues and Choleretics / therapeutic use*
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Cholangitis, Sclerosing / drug therapy*
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Fecal Microbiota Transplantation
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Fibroblast Growth Factors / analogs & derivatives
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Fibroblast Growth Factors / therapeutic use
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Gastrointestinal Microbiome
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Humans
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Immunologic Factors / therapeutic use*
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Isoxazoles / therapeutic use
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Janus Kinase Inhibitors / therapeutic use
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Liver Cirrhosis, Biliary / drug therapy*
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Peroxisome Proliferator-Activated Receptors / agonists*
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Propionates / therapeutic use
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Purines / therapeutic use
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Pyrazoles / therapeutic use
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Pyrazolones / therapeutic use
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Pyridones / therapeutic use
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Receptors, Cytoplasmic and Nuclear / agonists*
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Steroids / therapeutic use
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Sulfonamides / therapeutic use
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Tretinoin / therapeutic use
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Ursodeoxycholic Acid / therapeutic use
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Ustekinumab / therapeutic use
Substances
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2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid
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Anti-Bacterial Agents
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Azetidines
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Benzothiazoles
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Chalcones
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Cholagogues and Choleretics
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EDP-305
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Immunologic Factors
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Isoxazoles
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Janus Kinase Inhibitors
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Peroxisome Proliferator-Activated Receptors
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Propionates
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Purines
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Pyrazoles
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Pyrazolones
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Pyridones
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Receptors, Cytoplasmic and Nuclear
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Steroids
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Sulfonamides
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obeticholic acid
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farnesoid X-activated receptor
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Chenodeoxycholic Acid
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setanaxib
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Tretinoin
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Fibroblast Growth Factors
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Ursodeoxycholic Acid
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Abatacept
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Ustekinumab
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aldafermin
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baricitinib
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tropifexor
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Bezafibrate