Lung cancer is a global disease with high morbidity and mortality, which seriously affects human health. The long-term existence of chronic pulmonary inflammation is closely related to the occurrence and development of lung cancer, neutrophils are not only involved in acute and chronic inflammation, but also in the composition of tumor microenvironment (TME), which is closely related to the occurrence and development of tumors. Recent studies have found that tumor-associated neutrophils (TANs) play an important role in the occurrence and development of lung cancer. This article reviews the role, mechanism and clinical significance of tumor-related neutrophils in lung cancer.
【中文题目：肿瘤相关中性粒细胞与肺癌的相关研究进展】 【中文摘要：肺癌为全球性高发病率、高死亡率疾病，严重影响人类健康。其中肺部慢性炎症的长期存在与肺癌的发生发展关系密切，中性粒细胞不但参与急、慢性炎症反应，而且参与肿瘤微环境（tumor-microenvironment, TME）中的组成，与肿瘤的发生、发展密切相关。近年来研究发现，肿瘤相关中性粒细胞（tumor-associated neutrophils, TANs）在肺癌的发生和发展中发挥着重要的作用。本文就肿瘤相关中性粒细胞在肺癌中的作用、机制以及临床意义进行综述。】 【中文关键词：肿瘤相关中性粒细胞；肺肿瘤；肿瘤微环境；预后】.
Keywords: Lung neoplasms; Prognosis; Tumor microenvironment; Tumor-associated neutrophils.