Sepsis is one of the leading causes of inpatient deaths worldwide and is a major challenge in clinical work. The diagnosis and treatment of sepsis has been a research hotspot in critical care medicine. Through the efforts during the past decades, deeper understanding of the pathophysiology of sepsis and progress in the treatment have been made. But the latest sepsis guidelines and bundle strategies remain controversial, and clinical researches on sepsis are mixed. So far, there is no specific therapy for sepsis, and the mortality is still very high. Important researches and viewpoints in the field of sepsis in recent years are summarized and analyzed, so as to provide reference for the treatment of sepsis patients.